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NAG製品を使用した研究に関する各論文の概要

Keyword: cystic fibrosis, 嚢胞性線維症, 一様乱数

論文タイトル The Relationship between Genotype and Exercise Tolerance in Children with Cystic Fibrosis
出版情報 American journal of respiratory and critical care medicine, March 15, 2002 vol. 165 no.6
著者 HIRAN C. SELVADURAI, KAREN O. McKAY, CAMERON J. BLIMKIE, PETER J. COOPER, CRAIG M. MELLIS and PETER P. VAN ASPEREN
概要(abstract) "The relationship between fitness and genotype in children with cystic fibrosis(CF) and at least one copy of the ∆F508 mutation was examined."
"The class of cystic fibrosis transmembrance regulator proteins(CFTR) mutation was statistically related with aerobic capacity, peak anaerobic power, body mass index, lung function (forced expiratory volume in one second), and disease severity as measured by the Shwachman score."
"There were no statistically significant differences in the lung function of patients with the different mutations. These results indicate a relationship between CF genotype and some measures of fitness, the mechanisms of which remain to be determined."
使用されているNAG製品 研究のため、嚢胞性線維症(Cystic fibrosis)の病院に通院している8歳から12歳までの子供たちがランダムに選ばれている。このランダム化に使用される一様乱数の生成にNAG Fortran Library ルーチンGO5CBF 及び G05CAF が使用されている。

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